Brothers star heads o a road trip! Natalie Portman is to star in road trip comedy Best Buds. The actress will play a woman who experiences a personal crisis on the eve of her wedding. She then recruits two of her best friends and embarks on a marijuana-fueled journey to San Diego. Portman can currently be seen in Jim Sheridan’s Brothers. She will next be seen in medieval comedy Your Highness and Darren Aronofsky’s psychological thriller Black Swan.