Natalie Portman (‘Annihilation.’ ‘Jackie’) is set to take the lead role in ‘Pale Blue Dot,’ a sci-fi drama that will mark the directorial debut of  ‘Legion’ and ‘Fargo creator’ Noah Hawley.

Based on a screenplay by Brian C. Brown and Elliott DiGuiseppi, the film follows “a successful female astronaut who, after coming back home from a mission in space, starts to unravel when confronted by her seemingly perfect life. The film explores the theory that astronauts who spend long periods of time in space lose their sense of reality when they return home.”

Per Variety, John Hamm (‘Beirut.’ ’Baby Driver’) will play Portman’s fellow astronaut who she aggressively pursues after returning to Earth. Reese Witherspoon, who was initially set to star, will remain on board as producer with Bruna Papandrea, her partner at Pacific Standard.