Will Ferrell and John C. Reilly to Play HOLMES AND WATSON August 17, 2016 ‘Step Brothers’ and ‘Talladega Nights’ co-stars Will Ferrell and John C. Reilly are set to reunite for the Arthur Conan Doyle inspired comedy ‘Holmes & Watson,’ Deadline has learned. Etan Cohen is attached to direct from his own script, with Ferrell playing Sherlock Holmes and Reilly in the role of his faithful wingman, Doctor John Watson. Together the detective duo faces off against enemies from across the globe. The project was first announced back in 2008 with Ferrell starring alongside his ‘Talladega Nights’ co-star Sacha Baron Cohen, however the project stalled. Ferrell and his Gary Sanchez partner Adam McKay will produce the comedy with Mosaic. The team is hoping to begin filming towards the end of the year.