Rob Lowe to Melt July 21, 2010 Robe Lowe will Melt with You… Rob Lowe has joined the cast of upcoming indie film I Melt With You. The actor will co-star with Jeremy Piven and Thomas Jane in the indie thriller from director Mark Pellington. Lowe plays a doctor dealing with a personal loss and drug addiction, reports Deadline. The movie is said to explore themes including the pain of the modern male psyche. Filming is scheduled to begin next month in Northern California.