Mean Girls 2 Confirmed June 14, 2010 Mean Girls get meaner? A sequel to the 2004 comedy Mean Girls has been confirmed. According to reports, the sequel to the comedy will be directed by the Emmy-Award-winning Melanie Mayron. “The story revolves around a new high school student, Jo, who agrees to befriend an outcast, Abby, at the urging of Abby’s wealthy father in exchange for paying all of Jo’s costs for the college of her dreams. Jo and Abby team up to take on the school’s mean girls, the Plastics,” the press release said. “The story becomes a high stakes battle of loyalty that ultimately comes to a head when one of our heroines finds out that her friendship has been bought and paid for.” The synopsis suggests that the update will not include any of the original cast which included Lohan, Amanda Seyfried and Rachel McAdams.