McAdams cast in Sherlock Holmes September 25, 2008 Mean Girls actress to cast as ‘Holmes’ love interest Mean Girl Rachel McAdams has joined the cast of Guy Ritchie’s Sherlock Holmes revamp. The ‘Mean Girls’ actress will play Irene Adler, Holmes’s enigmatic love interest. The character appeared in one Sir Arthur Conan Doyle novel, 1891’s A Scandal In Bohemia, but the film incarnation is envisioned as a recurring character in a franchise. Also among the cast are Robert Downey Jr. as the Baker Street sleuth, Mark Strong as the villainous Blackwood and Jude Law as Holmes’s confidante Watson. Sherlock Holmes is scheduled for release in 2010.