‘Inherent Vice’ and ‘Irrational Man’ star Joaquin Phoenix is reportedly in talks to join John C. Reilly for the Patrick DeWitt adaptation ‘The Sisters Brothers.’

Set against the backdrop of the great California Gold Rush, the darkly comic tale follows siblings Eli and Charlie Sisters, hired gunslingers who have been ordered to track down and kill a prospector named Herman Kermit Warm.

Acclaimed French filmmaker Jacques Audiard (‘A Prophet,’ ‘Rust and Bone’) is attached to direct, with Reilly producing with Michael DeLuca (‘Inferno,’ ‘Captain Phillips,’ ‘Fright Night’).