Jessica Chastain has signed on to star in ‘Painkiller Jane,’ a big screen adaptation of Jimmy Palmiotti and Joe Quesada’s graphic novel series, Deadline has learned.

The vigilante drama centres on Jane Vasko, a New York City beat cop who is recruited to infiltrate a major drug and human trafficking ring. After a near death experience, she develops exceptional regenerative abilities that give her a unique indestructible advantage. With nothing to live for and no way to die, she becomes the vigilante Painkiller Jane, an unstoppable force of nature seeking revenge to those who destroyed her life as she leaves a path of death and destruction in her wake.

In addition to headlining, ‘Zero Dark Thirty’ star Chastain will produce the adaptation through her Freckle Films banner, alongside Lenny Beckerman of Lotus Entertainment and Solipsist Films’ Stephen L’Heureux (‘Sin City: A Dame To Kill For’). Bill Johnson, Jim Seibel, Ara Keshishian, and Palmiotti will serve as executive producers.

‘Painkiller Jane’ was previously brought to life with the 2005 made-for-TV movie starring Emmanuelle Vaugier. A short-lived series with Kristanna Lokken in the title role followed in 2007.

Chastain will next be seen in John Madden’s drama thriller ‘Miss Sloane’ when it is released in Irish cinemas in February.